Crews responded to a major wreck on I-81 northbound in Botetourt County Friday night.

The Roanoke Valley SPCA is asking for the public's help to look for a dog, Emmie, that went missing after a deadly crash on I-81 in Roanoke County on Monday.

ROANOKE COUNTY, Va. – The Cave Spring Volunteer Fire Department responded to a car wreck that sent one vehicle crashing into a creek. The department posted on Facebook about the incident around 2 p.m. on Saturday:“At approximately 11:30 this morning CSVFD was dispatched to the cross streets of Bent Mountain Rd and Cotton Hill Rd for the report of a motor vehicle accident with injuries. Upon arrival Wagon 3 found 1 vehicle had ran off the road into the creek. Members went to work securing the vehicle and getting the patient back across the creek. The patient then refused transport and all units then cleared.”