Patrick Mahomes threw two touchdown passes, rookie Jaylen Watson returned an interception 99 yards for the go-ahead fourth-quarter score, and the Kansas City Chiefs held on to beat the Los Angeles Chargers 27-24.

Trey Lance threw two touchdown passes and continued to make his case to be San Francisco’s Week 1 starter as the 49ers rallied for a 15-10 victory over the Los Angeles Chargers.

The Patriots, who can extend their NFL record to 11 consecutive playoff berths with a win, will also be missing a key offensive cog. ___KANSAS CITY-NEW ENGLANDChiefs: RB Damien Williams, CB Rashad Fenton, CB Morris Claiborne, OL Jackson Barton, OL Nick Allegretti, TE Deon Yelder, QB Chad Henne. Patriots: C Ted Karras, DL Byron Cowart, CB Joejuan Williams, QB Cody Kessler, OL Korey Cunningham, TE Ryan Izzo, RB Damien Harris. Bills: RB T.J. Yeldon, S Dean Marlowe, OG Ike Boettger, RT Ty Nsekhe, WR Duke Williams, TE Tommy Sweeney, DT Vincent Taylor. Packers: WR Ryan Grant, CB Kevin King, RB Dexter Williams, CB Tony Brown, CB Ka'dar Hollman, G/T Adam Pankey, T Yosh Nijman.