Spending the first half of the season as a spectator while he worked his way back from Achilles tendinitis took its toll on San Francisco 49ers All-Pro running back Christian McCaffrey.

San Francisco 49ers All-Pro running back Christian McCaffrey has looked good in his first week back at practice after being sidelined by Achilles tendinitis and is on track to make his season debut Sunday against Tampa Bay.

San Francisco 49ers star receiver Deebo Samuel has been released from the hospital after being treated for a bout of pneumonia.

San Francisco 49ers star receiver Brandon Aiyuk will miss the rest of the season after tearing ligaments in his right knee.

San Francisco 49ers rookie receiver Ricky Pearsall will be activated and make his NFL debut against Kansas City 50 days after he was shot in the chest.

Eight months later, the pain of losing a second Super Bowl in five seasons to the Kansas City Chiefs has barely subsided for the San Francisco 49ers as they prepare for a rare regular season rematch.

San Francisco 49ers rookie receiver Ricky Pearsall returned to the field for practice for the first time since he was shot in the chest during an attempted robbery nine days before the season opener.

San Francisco 49ers rookie receiver Ricky Pearsall is set to return to practice next week for the first time since he was shot in the chest in a robbery attempt nine days before the season opener.

San Francisco 49ers All-Pro running back Christian McCaffrey has traveled to Germany to consult with a specialist about his Achilles tendinitis.

Joshua Karty hit a 37-yard field goal with 2 seconds to play, and the Los Angeles Rams staged a spectacular late rally for a 27-24 victory over the San Francisco 49ers.

Injuries already are accruing across the NFL, knocking several star players out and forcing teams to turn to backups and reserves.

All-Pro running back Christian McCaffrey has been ruled out of this weekend’s game for the San Francisco 49ers because of his lingering calf and Achilles’ injuries.

San Francisco coach Kyle Shanahan said All-Pro running back Christian McCaffrey could have played in the 49ers’ opener if it had been a playoff game but the team held him out to make sure his Achilles tendinitis didn’t become a more serious issue.

San Francisco All-Pro running back Christian McCaffrey is listed as questionable for the season opener against the New York Jets with a sore calf and Achilles.

San Francisco 49ers rookie receiver Ricky Pearsall was at practice as a spectator five days after being shot in the chest during an attempted robbery.

Brandon Aiyuk’s first choice during his lengthy contract dispute with the 49ers that featured social media outbursts, a trade request and an awkward “hold in” was to remain in San Francisco.

San Francisco star receiver Brandon Aiyuk wasn’t at the start of practice despite the team saying he was cleared by doctors to participate.

Brock Purdy was efficient in completing 9 of 12 passes for 96 yards but also threw a red-zone interception as the San Francisco 49ers concluded their preseason with a 24-24 tie Friday night against the Las Vegas Raiders.

Contract disputes are playing a prominent role across the NFL this summer.

The San Francisco 49ers have rewarded All-Pro running back Christian McCaffrey with a contract extension after he won the AP Offensive Player of the Year award in his first full season with the team.

Quarterback Jimmy Garoppolo has signed with the Los Angeles Rams as the backup to Matthew Stafford.

The San Francisco 49ers are planning to cut their longest tenured player by releasing defensive tackle Arik Armstead in a salary cap move.

The San Francisco 49ers have promoted assistant Nick Sorensen to defensive coordinator and hired former Los Angeles Chargers coach Brandon Staley for a role on the team’s staff.

The San Francisco 49ers have fired defensive coordinator Steve Wilks three days after losing the Super Bowl to the Kansas City Chiefs.

The Kansas City Chiefs ended a nearly two-decade drought without a repeat champion in the NFL.

San Francisco 49ers coach Kyle Shanahan has heard the criticism that for some reason he is unable to win the big game.

The Kansas City Chiefs are a dynasty and already are looking to become the first team to three-peat in the Super Bowl era.

The Kansas City Chiefs beat the San Francisco 49ers 25-22 in overtime in a Super Bowl unlike any other.

San Francisco's decision to take the ball first in overtime of the Super Bowl will be debated for a while.

Coach Kyle Shanahan’s third trip to the Super Bowl ended up just like his first two.

Jauan Jennings’ historic Super Bowl milestone will turn into only a footnote after his San Francisco 49ers lost the game.

Despite a crushing Super Bowl loss, the 49ers are favorites to be next year’s NFL champions.

Kyle Shanahan can finally get past the Super Bowl hurdle and shed the label of a big-game coaching dud.

Nick Bosa has been making a high-profile impact for the San Francisco 49ers on Sundays ever since entering the league as the No. 2 overall pick in 2019.

The San Francisco 49ers had Patrick Mahomes and the Kansas City Chiefs on the ropes four years ago when the teams last met in the Super Bowl.

Lamar Jackson was a near-unanimous choice for his second AP NFL Most Valuable Player award.

When the Super Bowl was in the balance in the fourth quarter a year ago, coach Andy Reid’s Kansas City Chiefs put a twist on their frequent pre-snap motion.

Minutes after the San Francisco 49ers finished off a stunning comeback to win the NFC championship, star defender Nick Bosa pulled aside quarterback Brock Purdy and marveled at his journey.

Coach Kyle Shanahan took some convincing before deciding it was worth trading a boatload of draft picks before last season’s trade deadline for Christian McCaffrey.

Steve Wilks has had a roller coaster ride in his first season as defensive coordinator for the San Francisco 49ers.

The San Francisco 49ers made the kind of decision that could set a franchise back for years when they traded three first-round picks to draft Trey Lance third overall in 2021.

Kyle Shanahan’s offense is mimicked throughout the NFL as his innovative schemes are utilized by teams throughout the league.

The San Francisco 49ers finally climbed back up the playoff mountain to return to the Super Bowl only to find a familiar foe waiting for them.

Patrick Mahomes, Travis Kelce and the Kansas City Chiefs are heading to Las Vegas with a chance for a rare repeat while facing the San Francisco 49ers in a Super Bowl rematch from four years ago.

San Francisco 49ers wide receiver Deebo Samuel has been cleared to play in the the NFC championship game against the Detroit Lions after leaving last week’s game with a shoulder injury.

The San Francisco 49ers are back in a familiar spot facing a Detroit Lions team new to this stage.

Quarterback Brock Purdy will sit out the regular-season finale after the San Francisco 49ers have already wrapped up the No. 1 seed in the NFL playoffs.

NFL leading rusher Christian McCaffrey will miss San Francisco’s regular-season finale with a mild calf strain but should be ready to return for the playoffs.

If a December matchup between the top two teams in the NFL didn’t provide high enough stakes, the league MVP could be decided Monday night when the San Francisco 49ers host the Baltimore Ravens.

Brock Purdy threw three touchdown passes, including a 66-yarder to George Kittle, and the San Francisco 49ers seemingly fixed all their woes with a cross-country trip and a 34-3 drubbing of Jacksonville that ended a three-game skid.

Andy Reid again was a near-unanimous choice by The Associated Press for the top spot among NFL head coaches, receiving eight of nine first-place votes.

San Francisco 49ers quarterback Brock Purdy is in concussion protocol, putting his status for this week’s game against the Cincinnati Bengals in doubt.

The San Francisco 49ers are built to win with intelligence and toughness.

San Francisco 49ers receiver Deebo Samuel will miss at least the next two games with a hairline fracture in his shoulder.

Kyle Shanahan and Mike McDaniel spent years together scheming ways to exploit NFL defenses.

When the San Francisco 49ers dealt a bevy of draft picks to Carolina last October for Christian McCaffrey, some skeptics asked whether they overpaid for a running back in a passing league.

The San Francisco 49ers have given coach Kyle Shanahan and general manager John Lynch multi-year contract extensions.

Nick Bosa’s lengthy contract holdout ended four days before the start of the season for the San Francisco 49ers when he agreed to a contract extension that will make him the NFL’s richest defensive player ever.

Andy Reid couldn’t win the big one until he went to Kansas City and got Patrick Mahomes.

Few teams have ever invested as much capital into acquiring as the San Francisco 49ers did when they traded three first-round picks to draft Trey Lance.

Brock Purdy ran for a 5-yard touchdown during a brief tune-up for the season opener for San Francisco before the Los Angeles Chargers backups beat the 49ers 23-12 in the exhibition finale.

The San Francisco 49ers have traded quarterback Trey Lance to the Dallas Cowboys for a fourth-round pick less than three years after trading three first-round picks to draft him.

Sam Darnold has won the backup quarterback job in San Francisco, putting Trey Lance’s status with the 49ers in doubt less than three years after the team traded three first-round picks to draft him.

Brock Purdy knows the process of getting ready for the season after major elbow surgery in the offseason is a deliberate one with each day providing a new test.

San Francisco quarterback Brock Purdy has officially resumed his throwing program as he tries to return from offseason elbow surgery in time for the season opener.

The Chiefs and Eagles are bringing MVP finalists Patrick Mahomes and Jalen Hurts to the Super Bowl to cap a season in which the NFL had a glaring amount of instability at quarterback.

Nasty defenses.

Brock Purdy’s NFL career started with the moniker of “Mr. Irrelevant” and the weeklong trip to Newport Beach to celebrate the player picked last in the draft.

Jalen Hurts, Justin Jefferson and Patrick Mahomes are finalists for The Associated Press 2022 NFL Most Valuable Player and Offensive Player of the Year awards.

DeMeco Ryans’ day as San Francisco defensive coordinator started with meetings and then went to the practice field as he focused on implementing a defense to slow down Dak Prescott and the Dallas Cowboys.

For Kyle Shanahan, the chance to coach the San Francisco 49ers against the Dallas Cowboys in a playoff game is a throwback to when that rivalry was the biggest in football.

Brock Purdy threw three touchdown passes for his sixth straight game with multiple TDs and the San Francisco 49ers clinched the No. 2 seed in the NFC playoffs with a 38-13 victory over the Arizona Cardinals.

Jimmy Garoppolo threw four touchdown passes, including two each to Brandon Aiyuk and George Kittle, and the San Francisco 49ers won their third straight game by beating the Arizona Cardinals 38-10 in Mexico City.

Aaron Rodgers and his peers around the NFL are calling for teams to tear up their turf playing surfaces and replace them with grass.

Ron Rivera and Washington are making a habit of shocking undefeated teams.

There has already been two coaching changes halfway through the NFL season with Indianapolis firing Frank Reich this week four weeks after Carolina did the same to Matt Rhule.

Christian McCaffrey became the 11th player in NFL history with a rushing touchdown, a passing touchdown and a receiving touchdown in one game, and the San Francisco 49ers extended their regular-season mastery over the Rams to four full years with a 31-14 victory over Los Angeles.

San Francisco 49ers playmaker Deebo Samuel will miss Sunday’s key NFC West showdown against the rival Los Angeles Rams with an injured hamstring.

The most precarious lead in the NFL these days might be a double-digit one over Patrick Mahomes and the Kansas City Chiefs.

The fullback position in the NFL has been fading for years, but only in the last decade has it neared the brink of total extinction.

The Los Angeles Rams are used to making the NFL’s boldest moves and getting the big-name players they want.

General manager John Lynch still views his San Francisco 49ers as a Super Bowl contender despite a string of injuries, lackluster performances and a 3-3 start to the season.

The San Francisco 49ers have acquired star running back Christian McCaffrey from the Carolina Panthers for a haul of draft picks.

A protester who ran onto the field during the San Francisco 49ers’ home game against the Rams has filed a police report after being subdued by Los Angeles linebacker Bobby Wagner.

Bobby Wagner delivered one of the biggest hits on a person who got onto the field.

San Francisco 49ers quarterback Trey Lance will miss the rest of the season after breaking his right ankle.

Jimmy Garoppolo is staying in San Francisco after agreeing to a reduced contract to be the backup to Trey Lance on the 49ers.

San Francisco 49ers coach Kyle Shanahan started training camp with a declaration that second-year player Trey Lance will be the starting quarterback and Jimmy Garoppolo will be moving on soon.

Seven-time Pro Bowl center Alex Mack is retiring after 13 years in the NFL, leaving a major hole in the middle of the offensive line for the San Francisco 49ers.

Brian Griese decided on a career change this offseason after a 13-year run in the broadcast booth that included the last two as the analyst on “Monday Night Football.”.

The Las Vegas Raiders concluded organized team practices with all four quarterbacks on the roster participating but the buzz surrounding the franchise was about Colin Kaepernick, who has gotten a workout with the club.

Colin Kaepernick is getting his first chance to work out for an NFL team since last playing in the league in 2016 when he started kneeling during the national anthem to protest police brutality and racial inequality.

A year after having to rely solely on virtual visits the NFL returned to a normal spring evaluation process.

The San Francisco 49ers are hiring ESPN analyst Brian Griese as their new quarterbacks coach.

The Los Angeles Rams and Cincinnati Bengals got to the Super Bowl with help from a couple of coaching decisions by their conference title game opponents that backfired.

The Miami Dolphins have hired San Francisco 49ers offensive coordinator Mike McDaniel as their new coach, making him the first minority candidate to get hired so far this offseason.

Kyle Shanahan and Sean McVay arrived in California five years ago, a pair of hot-shot young coaches with a shared history and similar offenses taking over struggling franchises.

The Los Angeles Rams will host the San Francisco 49ers in the NFC championship game.

Cooper Kupp led the league in every major receiving category this season, a triple crown feat accomplished only three times previously in NFL history.

It was the rally that sparked the Green Bay Packers toward the NFL’s best regular-season record.