Photos of the protests, which have been happening intermittently since February, have shown people burning car tires and clashing with police in Port-au-Prince.
The United Nations reported Wednesday its humanitarian efforts have been impacted by the protests, affecting access to medical care and causing fuel shortages and lack of safe water.
Despite reports there have been casualties in clashes over the past few weeks, Haitian officials have yet to comment.
The "mega protest" Haitians have titled "Mobilizasyon san Limit," or "Unlimited Mobilization," is expected to begin around 10 a.m.
Journalist Etant Dupain reported from Port-au-Prince and CNN's Jackie Castillo, Taylor Barnes and Chandler Thornton reported and wrote in Atlanta.