San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.

Sam Darnold passed for 268 yards and two touchdowns against his former team, including a 97-yard strike in the second quarter to Justin Jefferson, and an attacking defense again fueled the Minnesota Vikings in a 23-17 victory over the San Francisco 49ers.

The San Francisco 49ers have no intention of granting star receiver Brandon Aiyuk his trade request and remain committed to getting a long-term extension done with one of their most important offensive players.

San Francisco 49ers coach Kyle Shanahan has heard the criticism that for some reason he is unable to win the big game.

Steve Wilks has had a roller coaster ride in his first season as defensive coordinator for the San Francisco 49ers.

The San Francisco 49ers made the kind of decision that could set a franchise back for years when they traded three first-round picks to draft Trey Lance third overall in 2021.

The San Francisco 49ers are back in a familiar spot facing a Detroit Lions team new to this stage.

Christian McCaffrey, Tyreek Hill and Fred Warner are unanimous choices for The Associated Press 2023 NFL All-Pro Team.

Brock Purdy and Tua Tagovailoa were selected to their first Pro Bowl as the starting quarterbacks for their respective conferences.

If a December matchup between the top two teams in the NFL didn’t provide high enough stakes, the league MVP could be decided Monday night when the San Francisco 49ers host the Baltimore Ravens.

Fred Warner is in the same spot as he was to start the season.

The San Francisco 49ers are built to win with intelligence and toughness.

Los Angeles Rams wide receiver Puka Nacua set the NFL single-game record for most receptions by a rookie with 15 catches in a 30-23 loss to the San Francisco 49ers.

Nick Bosa’s lengthy contract holdout ended four days before the start of the season for the San Francisco 49ers when he agreed to a contract extension that will make him the NFL’s richest defensive player ever.

The job of an off-ball linebacker has perhaps never been harder in the NFL.

The Washington Commanders are turning back to Carson Wentz as starting quarterback for their Week 17 game against the Cleveland Browns.

San Francisco forced two fumbles from Alvin Kamara to become the first team in nearly 21 years to hold New Orleans scoreless and the 49ers beat the Saints 13-0 for their fourth straight win.

Versatile receiver Deebo Samuel ran 26 yards for a touchdown the play after an interception by Dak Prescott and the San Francisco 49ers held on for a 23-17 wild-card victory over the Dallas Cowboys.

Russell Wilson played his best game since returning from finger surgery by throwing for 231 yards and two touchdowns and the Seattle Seahawks made a late goal line stand to beat the San Francisco 49ers 30-23.

(AP Photo/Stephen Brashear, File)Dynamic defensive star Aaron Donald and unstoppable tight end Travis Kelce were unanimous choices Friday for The Associated Press NFL All-Pro Team. Donald, who has helped the Los Angeles Rams to the top-ranked defense in the NFL, earned his sixth All-Pro selection. “I think the best display of greatness is making people around you better,” Rams coach Sean McVay said of Donald. Joining Donald and Kelce were 15 players returning to the squad, and 14 newcomers. Rounding out the offense were Cleveland right tackle Jack Conklin (second selection), and Washington right guard Brandon Scherff (first).

(AP Photo/Aaron Doster)Dallas running back Ezekiel Elliott is inactive against San Francisco with a calf injury the two-time rushing championship has been battling for several weeks. Safety Deon Bush (foot) is also out after being listed questionable with Johnson. Cowboys: RB Ezekiel Elliott, QB Ben DiNucci, WR Malik Turner, CB Rashard Robinson, DE Bradlee Anae, LB Luke Gifford, DE Ron’Dell Carter. ___JACKSONVILLE AT BALTIMOREJaguars: CB Sidney Jones, CB Luq Barcoo, LB Quincy Williams, DT Daniel Ross, QB Jake Luton. Ravens: DE Calais Campbell, CB Jimmy Smith, CB Marcus Peters, RB Mark Ingram, LB Kristian Welch, DE Jihad Ward, C Trystan Colon-Castillo.

The Niners will fly to Arizona, where they will practice, live and play their next two games after Santa Clara County imposed a three-week ban on games and practices for contact sports. (AP Photo/Ross D. Franklin, File)The San Francisco 49ers will finish out the regular season practicing and playing home games in Arizona after a ban on contact sorts in their home county was extended into January. The Niners relocated to Arizona at the beginning of December after Santa Clara County announced a three-week ban on contact sports games and practices to help slow the spread of the coronavirus. And, I think a lot of people are in the same boat.”The 49ers arrived in Arizona on Dec. 2 and began practicing the next day. The team is staying at a hotel near the Arizona Cardinals stadium in Glendale, where they are playing their home games.

Rookies Chase Young and Kamren Curl scored defensive touchdowns as Washington grabbed sole possession of first place in the division after a gritty 23-15 win over the San Francisco 49ers. He missed the second half with soreness in his surgically repaired right leg. “We were not clean today offensively,” San Francisco 49ers coach Kyle Shanahan said. Dwayne Haskins, the 15th overall pick in the 2019 draft, replaced Smith in the second half. San Francisco: travels to the Dallas Cowboys next Sunday.

The team said the positive test came back Wednesday morning and Bourne immediately went into self-quarantine after getting the diagnosis. The positive test came just days after the 49ers played at Seattle. All we can do right now is test and be aware of the connections.”This is the first positive coronavirus test for the 49ers since the start of the regular season. The Packers are dealing with their own issues with the coronavirus after running back AJ Dillon tested positive on Monday. Running back Jamaal Williams and linebacker Kamal Martin were placed on the COVID-19 list on Tuesday as “high-risk” contacts to Dillon.

– Jeff Wilson Jr. rushed for a career-high three touchdowns and 112 yards before leaving with an ankle injury and the San Francisco 49ers dominated in a 33-6 win over the New England Patriots on Sunday. San Francisco (4-3) has followed back-to-back losses with two wins and is 3-0 on the road. New England fell to 2-4 for the first since coach Belichick’s first season in 2000, when the Patriots went 5-11. Following a Patriots punt, San Francisco was pinned inside its 15. The lead grew to 23-3 with just under a minute to go before halftime on a 16-yard run by Wilson.