General manager John Lynch still views his San Francisco 49ers as a Super Bowl contender despite a string of injuries, lackluster performances and a 3-3 start to the season.

Wide receiver Emmanuel Sanders announced his retirement from the NFL on Wednesday after a 12-year career that included three Super Bowl appearances and a win in Super Bowl 50 with the Denver Broncos.

Receiver Robert Woods missed playing in the Rams' Super Bowl victory while recovering from a torn left ACL.

Another 21 NFL players were placed on the reserve/COVID-19 list Tuesday, including Kansas City Chiefs wide receiver Tyreek Hill, cornerback Rashad Fenton and tight end Blake Bell.

Tom Brady became the NFL’s all-time completions leader and threw his 700th touchdown pass for the winning score as the defending Super Bowl champion Tampa Bay Buccaneers got a 33-27 overtime victory over the Buffalo Bills on Sunday.

Ben Roethlisberger and the Steelers’ new-look offense overcame a slow start, Ulysees Gilbert returned a blocked punt 9 yards for a touchdown and Pittsburgh rallied to a season-opening 23-16 win over the Buffalo Bills.

FILE - San Francisco 49ers offensive tackle Trent Williams (71) looks on prior to an NFL football game against the Arizona Cardinals, in Glendale, Ariz., in this Saturday, Dec. 26, 2020, file photo. (AP Photo/Jennifer Stewart, File)As the NFL opened its business year Wednesday, veterans Trent Williams, A.J. The Seahawks addressed another need, agreeing to terms with tight end Gerald Everett on a one-year deal. Ad— Kansas City agreed to a $5 million contract for next season with three-time Pro Bowl guard Kyle Long, who will come out of retirement. — New England brought back center Ted Karras on a one-year, $4 million contract.

The Saints (12-4) will host the seventh-seeded Chicago Bears in the wild-card round next Sunday at 4:40 p.m. EST. He also ran for five TDs, but the Panthers struggled to make winning plays late in games all season with Bridgewater at the helm. That leaves questions about his future as the Panthers starting QB, especially with the team having a top 10 draft pick in 2021. UP NEXTSaints: The four-time defending NFC South champions host the Bears next Sunday in the playoffs. Panthers: After failing to make the playoffs for the third straight season, Carolina will look to the NFL draft to upgrade a number of pressing needs.

New Orleans Saints running back Alvin Kamara (41) breaks free past Minnesota Vikings cornerback Cameron Dantzler (27), outside linebacker Eric Wilson (50) and defensive end D.J. He finished with a career-high 155 yards rushing to help New Orleans beat the Minnesota Vikings 52-33 on Friday and clinch a fourth straight NFC South title. He has since set Saints records for rushing TDs in a season with 16 and total TDs with 21 (he has five receiving). It would be 8-yard gain, 7-yard gain.”The Saints (11-4) never punted, and set a record of yards gained in a game by a Vikings opponent with 583. New Orleans' 264 yards rushing were the most by a Vikings opponent in Zimmer's seven seasons.

Kansas City Chiefs quarterback Patrick Mahomes (15) passes in the first half of an NFL football game against the New Orleans Saints in New Orleans, Sunday, Dec. 20, 2020. (AP Photo/Brett Duke)NEW ORLEANS – Patrick Mahomes' repertoire of side-arm throws, basketball-style push passes, underhanded flips and renowned improvisation humbled yet another highly regarded defense. Mahomes passed for 254 yards and three touchdowns, and the Kansas City Chiefs extended their winning streak to nine games with a 32-29 victory over the New Orleans Saints on Sunday. Bell's score came one play after Saints defensive end Cameron Jordan was flagged for a personal foul and ejected for punching offensive lineman Andrew Wylie. With two timeouts remaining, the Saints kicked deep, but could not prevent Mahomes and Co. from running out the clock.

Philadelphia Eagles' Jalen Hurts scrambles during the first half of an NFL football game against the New Orleans Saints, Sunday, Dec. 13, 2020, in Philadelphia. (AP Photo/Chris Szagola)PHILADELPHIA – Jalen Hurts gave the Philadelphia Eagles more than just a spark. He had a 74-yard TD run against Pittsburgh and a 74-yard run against Baltimore. Hill connected with Jared Cook on a 20-yard TD pass to get the Saints within 24-21 with 1:29 left. Hurts tossed a 15-yard TD pass to Alshon Jeffery on fourth-and-2 to give the Eagles a 7-0 lead early in the second quarter.

Brees threw for 222 yards and four touchdowns, regaining the NFL career TD pass lead and lifting the New Orleans Saints into first place with a 38-3 rout of Brady and the Tampa Bay Buccaneers on Sunday night. The Saints intercepted Brady twice in a 34-23 season-opening win, with Janoris Jenkins returning one for a TD. “We didn't play well in any phase of the game,” Brady said. But with Tampa Bay’s offense sputtering and one of the league’s stingiest defenses unable to slow down Brees, New Orleans pressed on. Buccaneers: WR Chris Godwin (three catches, 41 yards) returned after missing one game with a broken right index finger.

Green Bay Packers quarterback Aaron Rodgers (12) drops back to pass under pressure from New Orleans Saints defensive lineman Malcom Roach in the first half of an NFL football game in New Orleans, Sunday, Sept. 27, 2020. (AP Photo/Butch Dill)NEW ORLEANS – Green Bay quarterback Aaron Rodgers sounds increasingly enamored with the scheme and play-calling philosophy of second-year head coach Matt LaFleur. The Packers are unbeaten and putting up some of the best offensive numbers in the NFL. Rodgers passed for 283 yards and three touchdowns, and the Packers scored 10 points in the final nine minutes to pull out a 37-30 victory over the New Orleans Saints on Sunday night. Emmanuel Sanders caught a 10-yard scoring pass at the end of the first half that gave the Saints a 17-13 lead.

(AP Photo/Brett Duke)NEW ORLEANS – Tom Brady was intercepted twice in his Tampa Bay debut, Alvin Kamara scored touchdowns running and receiving, and the New Orleans Saints beat the Buccaneers 34-23 on Sunday. Neither quarterback was statistically exceptional in this first-ever NFL game featuring two quarterbacks in their 40s. One exception was Saints safety and Players Coalition co-founder Malcolm Jenkins, who trotted to the Saints bench area after the anthem had finished. The Saints were flagged four times for 101 yards, with all of those calls occurring during the Bucs' first three scoring drives. Saints: Take part in the first NFL game played in Las Vegas, the Raiders' home opener on Monday night, Sept. 21.