Jamies Winston passed for five touchdowns, New Orleans intercepted reigning NFL MVP Aaron Rodgers twice, and the Saints kicked off the post-Drew Brees era with a strikingly dominant opening 38-3 victory over the Green Bay Packers.

From the season-altering (Dak Prescott, Barkley) to the bizarre (Tyrod Taylor, Trent Brown), injuries are playing their traditionally significant role in the NFL. (AP Photo/Charles Rex Arbogast, File)ARLINGTON, Texas – From the season-altering to the bizarre, injuries are playing their traditionally significant role in the NFL. Brown also recently went back on the COVID-19 list, a newcomer among potential ailments with the NFL playing during a pandemic. Few teams have had the volume of injuries that have hit defending NFC champion San Francisco. New Orleans' star receiver, Michael Thomas, has had a tumultuous season in part because of ankle and hamstring injuries.

Arizona Cardinals quarterback Kyler Murray (1) runs in a touchdown against New York Jets free safety Marcus Maye (20) during the first half of an NFL football game, Sunday, Oct. 11, 2020, in East Rutherford. (AP Photo/Seth Wenig)EAST RUTHERFORD, N.J. – The Arizona Cardinals certainly came to the right place to get back on the winning track. Having Kyler Murray and the offense put up nearly 500 yards against the hapless and winless Jets was almost predictable. “I don’t want anyone on the team to feel satisfied with what happened today," said Murray, who threw for 380 yards. Jets: play at Miami next Sunday as NFL reorganizes schedule due to coronavirus pandemic.

Start with running back, where Giants star Saquon Barkley is believed to have torn the ACL in his right knee early in their loss at Chicago. The 49ers' Jimmy Garoppolo tried to play through a right ankle injury before Nick Mullens took over for the second half. Tevin Coleman also left San Francisco's win over the Jets with a late knee injury. Along with Lock and Sutton, the Broncos lost defensive end Dre'Mont Jones to a knee injury in their defeat at Pittsburgh. Washington guard Brandon Scherff, who left early in Arizona with a knee injury, was among the offensive linemen hurt around the NFL on Sunday.

Still, short-handed San Francisco had enough to beat the inept New York Jets. Defensive end Nick Bosa and defensive tackle Solomon Thomas were both carted off the field two plays apart with left knee injuries in the first quarter. Two plays later, Thomas was carted off — also with a left knee injury — after an 8-yard reception by Chris Hogan. San Francisco ended the 14-play possession with an 18-yard catch by Jordan Reed for the first of his two TD grabs. ... San Francisco wide receiver Brandon Aiyuk, a first-round draft pick, had two catches for 21 yards in his NFL debut.