Xavier Watts intercepted Caleb Williams twice and returned a fumble for a touchdown as No. 21 Notre Dame harassed the Heisman Trophy winner and handed No. 10 Southern California its first loss in a 48-20 victory.

Sam Hartman threw three touchdown passes to move into seventh place on major college football’s career list and No. 9 Notre Dame pulled away from Central Michigan in the second half for a 41-17 victory.

Prince Kollie scored on a blocked punt, Benjamin Morrison returned an interception 96 yards for a touchdown and had another interception to set up another score as Notre Dame earned its second straight win over a ranked opponent, beating No. 5 Clemson 35-14.

Steven Gilmore returned an interception 37 yards for a touchdown late in the fourth quarter and Khalan Labron ran for 163 yards as Marshall shocked No. 8 Notre Dame 26-21.